C. Zurzolo

Tunneling nanotubes enable intercellular transfer in zebrafish embryos

This study demonstrates the presence of functional tunneling nanotubes (TNTs) in zebrafish embryos, showing their ability to transfer soluble cargoes and organelles.

N-Cadherin and alpha-catenin regulate formation of functional tunneling nanotubes

This study shows N-Cadherin and alpha-catenin regulate TNT formation and material transfer.

Proteomic landscape of tunneling nanotubes reveals CD9 and CD81 tetraspanins as key regulators

The paper identifies CD9 and CD81 tetraspanins as key regulators of tunneling nanotubes through proteomic analysis and functional studies.

Tunneling nanotubes between neuronal and microglial cells allow bi-directional transfer of α-Synuclein and mitochondria

This study shows that tunneling nanotubes between neurons and microglia enable bidirectional transfer of α-Synuclein and mitochondria, with implications for neurodegenerative disease spread.

A balance between actin and Eps8/IRSp53 utilization in branched versus linear actin networks determines tunneling nanotube formation

This study identifies how the balance between branched and linear actin network formation, mediated by Eps8 and IRSp53, determines tunneling nanotube (TNT) formation.

Tunneling nanotubes provide a novel route for SARS-CoV-2 spreading between permissive cells and to non-permissive neuronal cells.

This study shows SARS-CoV-2 uses tunneling nanotubes to spread between permissive cells and infect non-permissive neuronal cells.

Patient-derived Glioblastoma Stem cells transfer mitochondria through Tunneling Nanotubes in Tumor Organoids

This study shows that glioblastoma stem-like cells form functional tunneling nanotubes (TNTs) that enable mitochondria transfer in 2D and 3D tumor organoids, suggesting a role in therapy resistance.

A new form of actin assembly around the Shigella-containing vacuole regulates its intracellular niche

This study identifies a novel actin assembly mechanism around the Shigella-containing vacuole that subverts host regulators to create a protective actin cocoon.