T. Chaze

Mtfp1 ablation enhances mitochondrial respiration and protects against hepatic steatosis

This study shows that deleting Mtfp1 in hepatocytes increases mitochondrial respiration and protects against fatty liver disease.

Proteomic landscape of tunneling nanotubes reveals CD9 and CD81 tetraspanins as key regulators

The paper identifies CD9 and CD81 tetraspanins as key regulators of tunneling nanotubes through proteomic analysis and functional studies.

A balance between actin and Eps8/IRSp53 utilization in branched versus linear actin networks determines tunneling nanotube formation

This study identifies how the balance between branched and linear actin network formation, mediated by Eps8 and IRSp53, determines tunneling nanotube (TNT) formation.

Pneumococcus uses COMMD2 to alter host cellular immunity.

This study identifies COMMD2 as a bacterial factor that interacts with p65 and p62 to degrade p65, altering host cellular immunity during pneumococcal infection.

Mitochondrial fission process 1 (MTFP1) controls bioenergetic efficiency and prevents inflammatory cardiomyopathy and heart failure in mice

This study shows that MTFP1 is critical for cardiac function, as its loss in mice leads to dilated cardiomyopathy, heart failure, and death due to mitochondrial dysfunction and increased cell death.

Experimental evolution reveals post-transcriptional regulation as a novel driver of Leishmania fitness gain

This study shows that post-transcriptional regulation, not just genome instability, drives fitness gain in Leishmania parasites during in vitro adaptation.

Phosphorylation Dependent Assembly of a 14-3-3 Mediated Signaling Complex During Red Blood Cell Invasion by Plasmodium falciparum Merozoites

Revisiting Cryptococcus extracellular vesicles properties and their use as vaccine platforms

This paper characterizes the structural and compositional features of Cryptococcus extracellular vesicles and demonstrates their potential as vaccine candidates.

Characterization of extracellular vesicles produced by Aspergillus fumigatus protoplasts

This study characterizes extracellular vesicles from Aspergillus fumigatus protoplasts, showing they are produced across morphological stages and contain proteins and glycans related to metabolism and pathogenesis.

Cell-wall synthases contribute to bacterial cell-envelope integrity by actively repairing defects

The paper shows class-A penicillin-binding proteins (aPBPs), specifically PBP1b, repair cell-wall defects in E. coli to maintain integrity, independent of the Rod complex.

Transpeptidase PBP2 governs initial localization and activity of major cell-wall synthesis machinery in Escherichia coli

This study shows PBP2 initiates Rod complexes in E. coli by binding cell wall, not MreB or curvature, and limits Rod complex activity.

Listeria monocytogenes exploits the MICOS complex subunit Mic10 to promote mitochondrial fragmentation and cellular infection

This study identifies Mic10 as a host factor exploited by Listeria monocytogenes to induce mitochondrial fission and enhance cellular infection.