J. Enninga

Shigella generates distinct IAM subpopulations during epithelial cell invasion to promote efficient intracellular niche formation

This study identifies distinct IAM subpopulations during Shigella invasion that facilitate BCV disassembly through SNX8 and RAB11A recruitment.

Pneumococcus uses COMMD2 to alter host cellular immunity.

This study identifies COMMD2 as a bacterial factor that interacts with p65 and p62 to degrade p65, altering host cellular immunity during pneumococcal infection.

Salmonella endorses a dormant state within human epithelial cells for persistent infection

This paper identifies a dormant Salmonella Typhimurium subpopulation in human epithelial cells using a new fluorescent reporter, revealing distinct dormancy regulation compared to macrophages.

Salmonella subverts autophagy balancing bacterial fate and cellular inflammation

This study identifies c-MYC as a negative regulator of Salmonella Typhimurium cytosolic lifestyle and shows how LC3 and SopF modulate SCV stability to balance bacterial survival and host inflammation.

The histone demethylase KDM6B fine-tunes the host response to Streptococcus pneumoniae.

This study shows that KDM6B modulates the host response to Streptococcus pneumoniae by altering chromatin structure at the IL-11 promoter, affecting NF-κB activation.

A new form of actin assembly around the Shigella-containing vacuole regulates its intracellular niche

This study identifies a novel actin assembly mechanism around the Shigella-containing vacuole that subverts host regulators to create a protective actin cocoon.

SopB- and SifA-dependent shaping of the Salmonella-containing vacuole proteome in the social amoeba Dictyosteliumdiscoideum

This study identifies SopB and SifA as essential for Salmonella to modify the SCV proteome in Dictyostelium discoideum, enabling intracellular survival.

Identifying Parameters Of Host Cell Vulnerability During Salmonella Infection By Quantitative Image Analysis And Modeling

The paper identifies two sources of host cell vulnerability to Salmonella infection using image analysis and modeling, linking morphological and molecular parameters to infection success.