A Suite of Biochemical and Cell-Based Assays for the Characterization of KRAS Inhibitors and Degraders
M. Kidane, R. M. Hoffman, J. K. Wolfe-Demarco, T.-Y. Huang, C.-L. Teng, L. M. Gonzalez Lira, J. Lin-Jones, G. Pallares, J. E. Lamerdin, N. B. Servant, C.-Y. Lee, C.-T. Yang, J. A. Bernatchez
The paper develops biochemical and cell-based assays to evaluate KRAS inhibitors and degraders, generating selectivity profiles and dissociation constants for various KRAS mutants.
bioRxiv · Jul 20, 2024 · PreprintPharmacology & Toxicology