Author

J. A. Bernatchez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 4 Organism:human· 4 Research Focus:host-pathogen & immune response· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

J. L. Siqueira-Neto· 6 shared S. Beck· 4 shared Z. Zhu· 4 shared A. E. Clark· 3 shared B. W. Purse· 2 shared J. H. McKerrow· 2 shared L. A. Luna· 2 shared M. Coste· 2 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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6 shared papersMicrobiology

J. L. Siqueira-Neto

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6 papers

Recent·Most cited

Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in Glioblastoma.

A. Sen, B. C. Prager, D. Park, Z. Zhu, R. C. Gimple, J. A. Bernatchez, S. Beck, A. E. Clark, J. L. Siqueira-Neto, J. N. Rich, G. P. McVicker

This study identifies genes with allele-specific expression in glioblastoma stem cells, finding SLFN11 loss linked to drug resistance and susceptibility to Zika virus.

bioRxiv · Jun 22, 2021Cancer Biology

Identification of Leucinostatins from Ophiocordyceps sp. as Antiparasitic Agents Against Trypanosoma cruzi

J. A. Bernatchez, Y.-S. Kil, E. Barbosa da Silva, D. Thomas, L.-I. McCall, K. L. Wendt, J. M. Souza, J. Ackermann, J. H. McKerrow, R. H. Cichewicz, J. L. Siqueira-Neto

This study identifies leucinostatins from fungi as potent antiparasitic agents against Trypanosoma cruzi, with one showing in vivo efficacy in a mouse model.

bioRxiv · May 30, 2021Microbiology

High-throughput screening of the ReFRAME library identifies potential drug repurposing candidates for Trypanosoma cruzi

J. A. Bernatchez, E. Chen, M. V. Hull, C. W. McNamara, J. H. McKerrow, J. L. Siqueira-Neto

The paper screens 12,000 compounds from the ReFRAME library against Trypanosoma cruzi, identifying 7 with potent in vitro activity and therapeutic index ≥10.

bioRxiv · Dec 11, 2019Microbiology

Activity of Selected Nucleoside Analogue ProTides against Zika Virus in Human Neural Stem Cells

J. A. Bernatchez, M. Coste, S. Beck, G. A. Wells, L. A. Luna, A. E. Clark, Z. Zhu, C. D. Sohl, B. W. Purse, J. L. Siqueira-Neto

This study evaluates the antiviral activity of nucleoside ProTides against Zika virus in human neural stem cells, identifying effective compounds and elucidating their mechanism of action.

bioRxiv · Jan 29, 2019Microbiology

Mechanism of action of methotrexate against Zika virus

S. Beck, J. A. Bernatchez, Z. Zhu, M. F. Oliveira, D. M. Smith, J. L. Siqueira-Neto

This study investigates how methotrexate inhibits Zika virus replication by targeting the dihydrofolate reductase pathway and shows that adenosine depletion also contributes to its antiviral effect.

bioRxiv · Nov 29, 2018Microbiology

Development and validation of a phenotypic high-content imaging assay for assessing the antiviral activity of small-molecule inhibitors targeting the Zika virus

J. A. Bernatchez, Z. Yang, M. Coste, J. Li, S. Beck, Y. Liu, A. E. Clark, Z. Zhu, L. A. Luna, C. Sohl, B. W. Purse, R. Li, J. L. Siqueira-Neto

The paper develops and validates a high-content imaging assay to assess antiviral activity of small-molecule inhibitors against Zika virus by detecting cytopathic effects.

bioRxiv · Apr 17, 2018Microbiology