Author

C.-C. Chien

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Biophysics· 1 Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:Arabidopsis· 1 Research Focus:cell type annotation· 1 Research Focus:ecology & biodiversity· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

A. Gaitas· 1 shared B. Gong· 1 shared B. Thierry· 1 shared C.-R. Lee· 1 shared C.-T. Yang· 1 shared C.-Y. Lo· 1 shared G.-S. Chiu· 1 shared H.-C. Cheng· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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1 shared paperBiophysics

A. Gaitas

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

How weedy Arabidopsis thaliana dominated the world: ancestral variation and polygenic adaptation

C.-Y. Lo, C.-C. Chien, Y.-P. Lin, P.-M. Yeh, C.-R. Lee

This study identifies genetic factors underlying demographic turnover in Arabidopsis thaliana, showing polygenic adaptation contributes to the dominance of non-relict populations.

bioRxiv · Apr 28, 2024 · PreprintEvolutionary Biology

Hydrogen Sulfide Coordinates Glucose Metabolism Switch through Destabilizing Tetrameric Pyruvate Kinase M2

R.-H. Wang, P.-R. Chen, Y.-T. Chen, Y.-C. Chen, Y.-H. Chu, C.-C. Chien, P.-C. Chien, S.-Y. Lo, Z.-L. Wang, M.-C. Tsou, S.-Y. Chen, G.-S. Chiu, W.-L. Chen, Y.-H. Wu, L. Wang, , K.-T. Lin

This study shows hydrogen sulfide destabilizes PKM2 tetramer through sulfhydration at cysteine 326, rewiring glucose metabolism and inhibiting tumor growth.

bioRxiv · Sep 2, 2023Cancer Biology

AFM Microfluidic Cantilevers as Weight Sensors for Single Cell Mass Measurements

C.-c. Chien, J. Jiang, T. Li, B. Gong, A. Gaitas

This paper introduces microfluidic cantilevers for single-cell mass measurement, achieving sub-nanogram sensitivity and demonstrating improved performance with polymer materials.

bioRxiv · Feb 21, 2022Biophysics

Optical Cellular Micromotion: A New Paradigm to Measure Tumour Cells Invasion in 3D Tumour Environments

Z. Guo, C.-T. Yang, C.-C. Chien, L. Selth, P. Bagnaninchi, B. Thierry

This paper introduces optical cellular micromotion as a method to measure tumour cell invasion in 3D environments, showing it correlates with motility and responds to migrastatic drugs.

bioRxiv · Aug 26, 2021 · PreprintBioengineering