Peter M. Abadir

This study shows chronic CaMKII activation drives skeletal muscle aging and sarcopenia, and partial inhibition in aged muscle improves function and shifts the transcriptome toward a youthful state.

The paper develops a targeted proteomics method to quantify retinoid metabolism and signaling proteins across species and tissues, revealing tissue-specific networks and developmental changes in the heart.

This study shows that monocyte behaviors can predict aging and frailty in humans using single-cell analysis and a deep learning model.

The paper defines cognitive resilience as differential cognitive decline rates after adjusting for neuropathologies, develops a framework to quantify it using molecular signatures from post-mortem brain data, and translates these findings to living individuals.

This study translates post-mortem brain multi-omics AD dementia subtypes into blood, MRI, and psychological markers in living individuals.