Indomethacin exerts both cyclooxygenase inhibition-dependent and independent mechanisms to enhance chemo-immunotherapy in mice
Ogacheko D. Okoko, Nada S. Aboelella, Yan Ye, X Wang, Samson Eugin Simon, Md Yeashin Gazi, Victor J. Victor J. Enriquez Castro, Mercy Kehinde‐Ige, Caitlin Brandle, Dongwen Lv, David W. Wolff, Catherine C. Hedrick, Gary Anthony Piazza, Huidong Shi, Gang Zhou
This study shows indomethacin enhances chemo-immunotherapy in mice through both COX-dependent and independent mechanisms, including RAS inhibition.
bioRxiv · Jan 8, 2026 · PreprintImmunology