Astrocyte growth during morphogenesis is driven by the Tre1/S1pr1 phospholipid-binding G protein-coupled receptor
Jiakun Chen, Tobias Stork, Yunsik Kang, Katherine Nardone, Franziska Auer, Ryan J. Farrell, Taylor R. Jay, Dongeun Heo, Amy E. Sheehan, Cameron Paton, Katherine I. Nagel, David Schoppik, Kelly R. Monk, Marc R. Freeman
The paper identifies Tre1 and S1pr1 as evolutionarily conserved regulators of astrocyte morphology through lipid signaling and competition for growth-promoting phospholipids.
Neuron · Dec 13, 2023Peer-reviewedNeuroscience