Dongeun Heo

The paper introduces a CRISPR-Cas13d-based system for cell-specific mRNA knockdown in zebrafish, validated across CNS glia types, showing efficient target mRNA depletion and reproducible phenotypes.

This study shows that PIEZO1 and PIEZO2 channels in oligodendrocytes regulate sheath formation, expansion, and myelination by detecting mechanical cues.

The paper shows that retinal ganglion cell activity induces correlated astrocyte calcium waves in the superior colliculus, dependent on mGluR5 and mGluR3, suggesting a conserved mechanism across sensory systems.

This study investigates how aging affects oligodendrocyte precursor cells (OPCs) by analyzing their transcriptional profiles across the lifespan using single-cell RNA sequencing.

The paper identifies Tre1 and S1pr1 as evolutionarily conserved regulators of astrocyte morphology through lipid signaling and competition for growth-promoting phospholipids.

This study shows that TDP-43 loss affects oligodendrocyte survival and myelination differently at various stages of maturation, leading to morphological defects and neurological impairments.