Amy E. Sheehan

Developmental and age-related synapse elimination is mediated by glial Croquemort

This study identifies glial Croquemort as a key regulator of synapse elimination during development and aging in Drosophila.

An Ionic Sensor acts in Parallel to dSarm to Promote Neurodegeneration

The paper identifies dWnk as an ionic/osmotic sensor that promotes neurodegeneration alongside dSarm in Drosophila, converging on Axundead for axon death.

Astrocyte growth during morphogenesis is driven by the Tre1/S1pr1 phospholipid-binding G protein-coupled receptor

The paper identifies Tre1 and S1pr1 as evolutionarily conserved regulators of astrocyte morphology through lipid signaling and competition for growth-promoting phospholipids.

Astrocyte-dependent local neurite pruning and Hox gene-mediated cell death in Beat-Va neurons

The paper identifies two neuronal subtypes in Drosophila that undergo distinct remodeling processes during metamorphosis, highlighting astrocyte-dependent pruning and Hox gene-mediated cell death.

Tweek-dependent formation of ER-PM contact sites enables astrocyte phagocytic function and remodeling of neurons

This study shows Tweek is essential for astrocyte phagocytosis and ER-PM contact formation during neuronal remodeling in Drosophila.

Discoidin domain receptor regulates ensheathment, survival, and caliber of peripheral axons

This study identifies Ddr as a key regulator of non-myelinating glial ensheathment and its role in axon survival and caliber in Drosophila.

Glial TGFβ activity promotes axon survival in peripheral nerves

The paper identifies glial TGFβ signaling as essential for axon survival and shows its loss leads to age-dependent neurodegeneration.