Charles E. Murry

The paper investigates how sex chromosome aneuploidy affects gene expression and DNA methylation in different cell types, revealing cell-type specific dosage compensation mechanisms.

The paper uses O-MAP to study a cardiac-specific RNA factory around TTN RNA, revealing its chromatin interactions, RNA composition, and role of RBM20 in gene regulation.

This study uses hiPSC-derived cardiomyocytes to assess MYH7 variants' effects, showing pathogenic variants reduce protein abundance and cell survival.

CRaTER enriches for on-target gene-edited cells in hiPSCs, enabling efficient generation of variant libraries for studying cardiomyopathy-associated mutations.

This study shows that MYH7 E848G mutation causes cardiomyocyte apoptosis and contractile dysfunction in a stem cell model of HCM, independent of p53.

This study investigates how 3D chromatin organization changes during human endothelial cell differentiation and links these changes to gene expression and transcriptional regulation.

The paper investigates how lamin A/C haploinsufficiency affects chromatin compartments and gene expression in human cardiomyocytes, finding limited compartmental changes despite electrophysiological and gene expression alterations.

The paper studies how nuclear architecture changes during human heart development using Hi-C, RNA-seq, and ATAC-seq, revealing dynamic chromosomal organization and gene regulation.

This paper introduces nanoMEAs to enhance the structural and functional properties of hPSC-derived cardiomyocytes and neurons, improving their response to pharmacological agents.

The paper maps cardiac differentiation at single-cell resolution, identifies HOPX dysregulation, and shows hypertrophic signaling is required for HOPX transcription in hPSC-derived cardiomyocytes.

Isolator improves isoform-level RNA-Seq analysis by reducing variance and increasing agreement between samples through a Bayesian hierarchical model and bias correction.