Wenxiu Ma

The paper investigates how cohesin acetylation and ATPase activity regulate chromatin loop formation and cohesion in yeast, showing they operate through distinct mechanisms.

The paper investigates how sex chromosome aneuploidy affects gene expression and DNA methylation in different cell types, revealing cell-type specific dosage compensation mechanisms.

DiffGR detects differentially interacting genomic regions between Hi-C contact maps by comparing TAD-level interactions in human and mouse datasets.

This study shows that KDM6A is required for Xist upregulation during X inactivation initiation in mouse ES cells, as its knockout impairs Xist RNA coating and leads to aberrant Xi gene expression.

ASHIC improves diploid Hi-C analysis by modeling allele-specific chromatin structures, outperforming existing methods in low coverage and low SNP density scenarios.

This study shows KDM6A differentially regulates maternal and paternal alleles in mouse genes, with distinct chromatin changes depending on the allele.

This paper introduces DNase Hi-C and targeted DNase Hi-C methods for high-resolution mapping of chromatin interactions, overcoming limitations of traditional Hi-C techniques.

The paper introduces a sequence+shape kernel to model transcription factor binding without requiring aligned binding sites, showing improved prediction of binding affinity across different k values.