High-Throughput Screening Identifies Small-Molecule Inhibitors of the Tau-LRP1 Interaction
Caiqin Wang, Chen-Ting Ma, Camryn Crotty, Fu‐Yue Zeng, Andrey A. Bobkov, Jonathan A. Covel, Erica Keane Rivera, Eduard A. Sergienko, Kenneth S. Kosik, Steven H. Olson, Michael R Jackson, Jennifer N. Rauch
This study identifies small-molecule inhibitors of the tau-LRP1 interaction using biochemical assays and high-throughput screening, showing reduced tau uptake in cellular assays.
bioRxiv · Sep 2, 2026 · PreprintBiochemistry