Eduard A. Sergienko

This study identifies small-molecule inhibitors of the tau-LRP1 interaction using biochemical assays and high-throughput screening, showing reduced tau uptake in cellular assays.

This study shows how non-coding variants in CD33 affect Alzheimer's risk by altering CD33M dimerization and interactions with clusterin and Aβ, impacting microglial function.

The paper develops BiTSA, a bioluminescence-based thermal stability assay, to characterize isoform-dependent thermal stability of ApoE variants in living cells and confirms that ApoE4 is less stable than ApoE3 in native tissue.

The paper identifies an uncompetitive allosteric inhibitor of mitochondrial creatine kinase that stabilizes loop closure, preventing creatine binding and phosphocreatine release.

This study shows LARP6 regulates fibrogenic gene translation in liver fibrosis by interacting with collagen mRNAs and reducing fibrosis in human HSCs.

This study identifies M19-6 as a small molecule that disrupts the eIF4F complex, reducing melanoma growth and metastasis while sparing melanocytes.

The paper investigates the structural and mechanistic features of mitochondrial creatine kinase (uMtCK) and evaluates the efficacy of a covalent inhibitor in breast cancer cells.