Small molecule inhibition of the mitochondrial lipid transfer protein STARD7 attenuates influenza viral replication
Shipra Sharma, Oyahida Khatun, Jihaan Adonis, Shaochen You, Kevin Hartenbower, Vedita Anand Singh, Namir Shaabani, Saikat De, Emi R. Matsuo, Rachel Y. Sattler, Jonathan A. Covel, Kris M. White, Laura Martin‐Sancho, Malina A. Bakowski, Dylan J. Mendonsa, , Sumit K. Chanda
This paper identifies a small molecule, M4, that inhibits influenza A and B replication by targeting the host protein STARD7, preventing vRNP nuclear export and demonstrating synergistic antiviral effects with baloxavir in mice.
PLoS Pathogens · Sep 11, 2026Peer-reviewedMicrobiology