Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive demethylation in mammals
Christopher B. Mulholland, Atsuya Nishiyama, Joël Ryan, Ryohei Nakamura, Merve Yiğit, Ivo M. Glück, Carina Trummer, Weihua Qin, Michael D. Bartoschek, Franziska R. Traube, Edris Parsa, Enes Ugur, Miha Modic, Aishwarya Acharya, Paul Stolz, , Heinrich Leonhardt
The paper identifies DPPA3 as a driver of genome-wide passive DNA demethylation in mammals, showing it can bypass TET protein requirements and function across species.
bioRxiv · Apr 4, 2020 · PreprintDevelopmental Biology