An Fc-silent OspA monoclonal antibody passively protects mice from tick and intradermal Borrelia burgdorferi challenge
Daniel Palmer, Atieh Shemshadian, Katherine Berman, Ariana Nobles, Graham G. Willsey, Carol Lyn Piazza, Grace Freeman-Gallant, Michael J. Rudolph, Jeffrey S. Bourgeois, Linden Hu, David J. Vance, Nicholas John Mantis
This study shows that an Fc-silent variant of the monoclonal antibody LA-2 provides equivalent passive protection against Borrelia burgdorferi in mice, suggesting its protective mechanism is independent of complement.
PLoS ONE · Mar 12, 2026Peer-reviewedImmunology