Author

Linden Hu

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:long-read sequencing· 1 Organism:mouse· 1

Frequent Co-Authors

Alexander ArvanitisiD· 1 shared Ali A Djarou· 1 shared Allen C. SteereiD· 1 shared Ariana Nobles· 1 shared Ashlee M. EarliD· 1 shared Atieh Shemshadian· 1 shared Ben KotzeniD· 1 shared Brenda Rosario Perez· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMicrobiology

Alexander ArvanitisORCID

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Author profile →

2 papers

Recent·Most cited

An Fc-silent OspA monoclonal antibody passively protects mice from tick and intradermal Borrelia burgdorferi challenge

Daniel Palmer, Atieh Shemshadian, Katherine Berman, Ariana Nobles, Graham G. Willsey, Carol Lyn Piazza, Grace Freeman-Gallant, Michael J. Rudolph, Jeffrey S. Bourgeois, Linden Hu, David J. Vance, Nicholas John Mantis

This study shows that an Fc-silent variant of the monoclonal antibody LA-2 provides equivalent passive protection against Borrelia burgdorferi in mice, suggesting its protective mechanism is independent of complement.

PLoS ONE · Mar 12, 2026Peer-reviewedImmunology

Linkage blocks involving multiple replicons organize Borrelia burgdorferi strain variation and influence virulence in Lyme disease

R Laing, Michael Joshua Foster, M. Amine Hassani, Ben Kotzen, Alexander Arvanitis, Weihua Huang, Terrence Shea, Ali A Djarou, Gordon C. Adams, Stephen F. Schaffner, Tjasa Cerar, Lisa M. Freimark, Eva Ružić‐Sabljić, Dionysios Liveris, Radha Iyer, , Jacob E. Lemieux

This study uses long-read assemblies to show that genetic modules across multiple plasmids organize Borrelia burgdorferi strain variation and influence virulence in Lyme disease.

bioRxiv · Jan 29, 2025 · PreprintMicrobiology