Nuclear RNAi Modulates Influenza A Virus Infectivity By Downregulating Type-I Interferon Response
Hsiang-Chi Huang, Iwona Nowak, Vivian Lobo, Danica F. Besavilla, Karin Schön, Jakub O. Westholm, Carola Fernandez, Angana A.H. Patel, Clotilde Wiel, Volkan I. Sayin, Dimitrios G. Anastasakis, Davide Angeletti, Aishe A. Sarshad
This study shows that influenza A virus exploits nuclear RNAi by inducing AGO2 accumulation and silencing type-I interferon genes, and that arsenic trioxide can counteract this effect.
bioRxiv · Mar 7, 2024 · PreprintBiochemistry