Design of allosteric modulators that change GPCR G protein subtype selectivity
Madelyn N. Moore, Kelsey L. Person, Valeria L. Robleto, Abigail R. Alwin, Campbell L. Krusemark, Noah Foster, Caroline Ray, Asuka Inoue, Michael R. Jackson, Michael J. Sheedlo, Larry S. Barak, Ezequiel Marrón Fernández de Velasco, Steven H. Olson, Lauren M. Slosky
This study designs allosteric modulators that alter GPCR G protein subtype selectivity by targeting the receptor-transducer interface, demonstrating predictable mechanisms for rational drug design.
Nature · Oct 22, 2025Peer-reviewedPharmacology & Toxicology