Ezequiel Marrón Fernández de Velasco

This paper develops AAV-m5, a nanobody-functionalized AAV vector that targets neurons via mGluR5, achieving efficient and specific transduction in the CNS without relying on promoters.

This paper develops an AAV-only method to target VTA dopamine neurons in mice for optogenetic studies, achieving high efficiency and fidelity.

This study designs allosteric modulators that alter GPCR G protein subtype selectivity by targeting the receptor-transducer interface, demonstrating predictable mechanisms for rational drug design.

This study investigates how NMDAR ablation in adolescent mice affects synaptic structure and function in the medial prefrontal cortex, revealing early disruption followed by compensatory recovery.

The paper identifies nucleus accumbens inhibitory interneurons as a key site where mu opioid receptor expression promotes social behavior, distinct from its role in exogenous opioid sensitivity.

The paper shows mild depolarization in neurons triggers immediate early genes and temporarily reduces responses to subsequent stimuli.

This study compares the transduction efficiency of AAV9 and AAV2retro vectors in the somatosensory system using reporter expression in transgenic mice.

The paper investigates how enhancing pyramidal neuron excitability in the prelimbic cortex affects behavior, finding that such manipulations replicate cocaine-induced behavioral changes.