Michael R. Jackson

Automation workflow for high-throughput arrayed plasmid DNA preparation and quantification.

The paper describes an automated workflow for high-throughput plasmid DNA preparation and quantification using a robotic workstation, achieving high yields and quality with minimal human intervention.

Automation of high-throughput workflow for arrayed CRISPR activation library screening

This paper develops an automated high-throughput workflow for arrayed CRISPRa screening, demonstrating its effectiveness in identifying growth reduction phenotypes in HEK293 cells.

Design of allosteric modulators that change GPCR G protein subtype selectivity

This study designs allosteric modulators that alter GPCR G protein subtype selectivity by targeting the receptor-transducer interface, demonstrating predictable mechanisms for rational drug design.

Targeting the translation initiation complex in therapy-resistant and metastatic melanoma

This study identifies M19-6 as a small molecule that disrupts the eIF4F complex, reducing melanoma growth and metastasis while sparing melanocytes.