Signal Peptide Peptidase-Like 2b affects APP cleavage and exhibits a biphasic Aβ-mediated expression in Alzheimer's disease.
Riccardo Maccioni, Caterina Travisan, Stefania Zerial, Annika Wagener, Yuniesky Andrade‐Talavera, Federico Picciau, Caterina Grassi, Gefei Chen, Laëtitia Lemoine, André Fisahn, Richeng Jiang, Regina Fluhrer, Torben Mentrup, Bernd Schröder, Per Nilsson, Simone Tambaro
This study shows that SPPL2b affects APP cleavage and has biphasic Aβ-mediated expression in Alzheimer's disease, suggesting it as a potential drug target.
bioRxiv · Oct 24, 2022 · PreprintNeuroscience