Catherine Kelly

Individualised mapping of living human brain mitochondria by MRI reveals signatures of bioenergetic defects.

This paper introduces a neuroimaging framework to map brain mitochondria non-invasively and finds age-related declines in mitochondrial density and respiratory capacity, along with disease-specific alterations and links to systemic stress and cognition.

Development and validation of a gene expression score to account for tumour purity and improve prognostication in breast cancer

This paper develops and validates a 9-gene Breast Cancer Purity Score to improve prognostication by accounting for tumour purity in breast cancer datasets.

The energetic stress cytokine GDF15 is elevated in the context of chronic and acute psychosocial stress

This paper shows that GDF15 levels rise with psychosocial stress, depression, anxiety, and biological aging, and that saliva GDF15 has a distinct diurnal pattern and responds rapidly to acute stress.