Postnatal Sensory Experience and Barrel Cortex Alterations Anticipate Autistic Traits in a Mouse Model of Cdkl5 Deficiency Disorder
Alessandra Raspanti, Riccardo Pizzo, Antonia Gurgone, Cecilia Giraudo, Giulia Sagona, Andrea Macioce, Anthony Battaglia, Lamprini Katsanou, Debora Comai, Giorgio Medici, Francesco Ferrini, Tommaso Pizzorusso, Elisabetta Ciani, Maurizio Giustetto
This study shows that CDKL5 deficiency in mice leads to sensory processing defects in the barrel cortex and autistic traits, which can be rescued by neonatal CDKL5 replacement.
Progress in Neurobiology · Aug 19, 2026Peer-reviewedNeuroscience