Leukemia stem cell expansion cultures reveal clonal drivers of leukemogenesis and therapy response
Indranil Singh, Andrea Polazzi, Alex Maya Pombo, Marta López-Osias, Celine Bauer, Maria Guarini, Pedro Sánchez-Sánchez, Luna Goulet, Carmen Gallardo, Daniel Fernández-Pérez, Robert L. Bowman, Alejo Rodriguez-Fraticelli
This paper develops PLSTCs to expand AML LSCs and identifies clonal drivers of leukemogenesis and therapy response through genomic and single-cell analyses.
bioRxiv · Feb 25, 2026 · PreprintCancer Biology