Daniel Fernández-Pérez

This study uses single-cell transplantation and mathematical modeling to show that lineage biases in hematopoiesis arise from extrinsic feedback and clonal competition, not intrinsic HSC properties.

This paper develops PLSTCs to expand AML LSCs and identifies clonal drivers of leukemogenesis and therapy response through genomic and single-cell analyses.

The paper develops STRACK to trace clonal gene expression and expansion dynamics in leukemia, showing pre-existing stem cell heterogeneity dictates clonal responses to cancer mutations.

This study identifies Ro5-3335 as a chemical that increases HSC clone number and clonal diversity by altering RUNX1 binding partners in zebrafish and mouse models.

This study shows BAP1 regulates PcG occupancy and chromatin condensation by limiting H2AK119ub1 deposition, revealing its role in counteracting PCGF3/5-dependent PRC1 activity.

This study shows that H2AK119ub1 deposition is essential for maintaining PcG-target gene repression in ESCs by coordinating PRC1 and PRC2 activities.