Cell BiologyNature Cell BiologyPeer-reviewed
A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells
Esther Rodriguez-Correa, Florian Grünschläger, Tamar Nizharadze…·Michael D. Milsom
This study uses single-cell transplantation and mathematical modeling to show that lineage biases in hematopoiesis arise from extrinsic feedback and clonal competition, not intrinsic HSC properties.