JNK pathway suppression drives resistance to combination endocrine therapy and CDK4/6 inhibition in ER+ breast cancer
Sarah Alexandrou, Christine S Lee, Kristine J. Fernandez, Celine E Wiharja, Leila Eshraghi, John Reeves, Daniel A. Reed, Neil Portman, Zoe Phan, Heloisa Helena Milioli, Iva Nikolić, Antonia L. Cadell, David R. Croucher, Kaylene J. Simpson, Elgene Lim, , Catherine Elizabeth Caldon
This study identifies JNK pathway suppression as a driver of resistance to combination endocrine therapy and CDK4/6 inhibition in ER+ breast cancer, with implications for patient stratification.
bioRxiv · Jan 8, 2025 · PreprintCancer Biology