Author

Chahrazad Lachiheb

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Casper F. T. van der VeniD· 2 shared Dimitrios L. WagneriD· 2 shared Emily Ohlendorf· 2 shared Jonas KathiD· 2 shared Julia MacosiD· 2 shared Kathleen AndersiD· 2 shared Maria StecklumiD· 2 shared Maximilian PilgramiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioengineering

Casper F. T. van der VenORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

A Non-Viral CRISPR/Cas9 HDR Platform for Stable Engineering of Solid Tumor Models.

Shoaib Afzal, Maximilian Pilgram, Julia Macos, Emily Ohlendorf, Lena Olivia Raab, Jonas Kath, Viktor Glaser, Ana-Maria Nitulescu, Casper F. T. van der Ven, Chahrazad Lachiheb, Maria Stecklum, Norman Michael Drzeniek, Kathleen Anders, Dimitrios L. Wagner, Ralf Kuehn, , Michael Launspach

This paper develops a non-viral CRISPR/Cas9 HDR platform for stable transgene knock-in in solid tumor models, achieving up to 60% efficiency in neuroblastoma cells.

bioRxiv · Jun 4, 2026 · PreprintBioengineering

Personalized CRISPR Knock-In Cytokine Gene Therapy to Remodel the Tumor Microenvironment and Enhance CAR T Cell Therapy in Solid Tumors

Michael Launspach, Julia Macos, Shoaib Afzal, Janik Hohmann, Marc L Appis, Maximilian Pilgram, Stefanie Beez, Emily Ohlendorf, Casper F. T. van der Ven, Chahrazad Lachiheb, Karin Toews, Lena Andersch, Marvin Jens, Felix Zirngibl, Jonas Kath, , Annette Künkele

This paper develops CancerPAM, a bioinformatics pipeline for identifying CRISPR knock-in sites to remodel the tumor microenvironment, enhancing CAR T cell therapy in solid tumors.

Nature Communications · Dec 9, 2025Peer-reviewedBioengineering