Author

Tianhe Xiao

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Ayijiang YisimayiiD· 3 shared Fanchong JianiD· 3 shared Jing WangiD· 3 shared Weiliang Song· 3 shared Xiao Niu· 3 shared Youchun WangiD· 3 shared Yuanling YuiD· 3 shared Yunlong CaoiD· 3 shared

Activity by Year

2019-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Ayijiang YisimayiORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Intratumoral gene delivery of 4-1BBL boosts IL-12-triggered anti-glioblastoma immunity

Taral R. Lunavat, Lisa Nieland, Sanne M. van de Looij, Alexandra J E M de Reus, Charles Couturier, Chadi A. El Farran, Tyler E. Miller, Julia K. Lill, Maryam Schübel, Tianhe Xiao, Emilio Di Ianni, Elliot C. Woods, Yi Sun, David Rufino‐Ramos, Thomas S. van Solinge, , Koen Breyne

This study shows that delivering 4-1BBL via AAV enhances IL-12-induced anti-glioblastoma immunity in mouse models by boosting CD8 T cell activity and survival.

bioRxiv · Feb 3, 2025 · PreprintCancer Biology

Omicron-specific ultra-potent SARS-CoV-2 neutralizing antibodies targeting the N1/N2 loop of Spike N-terminal domain

Xiao Niu, Zhiqiang Li, Jing Wang, Fanchong Jian, Yuanling Yu, Weiliang Song, Ayijiang Yisimayi, Shuo Du, Zhiying Zhang, Qianran Wang, Ran An, Yao Wang, Peng Wang, Haiyan Sun, Lingling Yu, , Yunlong Cao

This study identifies ultra-potent Omicron-specific antibodies targeting the N1/N2 loop of the Spike NTD, which neutralize SARS-CoV-2 by competing with ACE2 and blocking S1 shedding, but are evaded by BA.2.86 and BA.2.87.1 sublineages.

Emerging Microbes & Infections · Oct 3, 2024Peer-reviewedImmunology

Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1

Fanchong Jian, Jing Wang, Ayijiang Yisimayi, Weiliang Song, Yanli Xu, Xiaosu Chen, Xiao Niu, Sijie Yang, Yuanling Yu, Peng Wang, Haiyan Sun, Lingling Yu, Yao Wang, Ran An, Wenjing Wang, , Yunlong Cao

This study analyzes the humoral immune response to SARS-CoV-2 XBB and JN.1 lineages, showing JN.1 elicits superior neutralization and highlights the need for JN.1-based vaccine boosters.

bioRxiv · Apr 19, 2024Immunology

Viral evolution prediction identifies broadly neutralizing antibodies against existing and prospective SARS-CoV-2 variants

Fanchong Jian, Anna Z. Wec, Leilei Feng, Yuanling Yu, Lei Wang, Peng Wang, Lingling Yu, Jing Wang, Jacob Hou, Daniela Montes Berrueta, Diana Lee, Tessa Speidel, LingZhi Ma, Thu Kim, Ayijiang Yisimayi, , Yunlong Cao

This paper predicts SARS-CoV-2 RBD evolution using deep mutational scanning to identify broadly neutralizing antibodies effective against existing and prospective variants.

bioRxiv · Apr 16, 2024Immunology

CRISPR screening of porcine sgRNA library identified host factors essential for Japanese encephalitis virus replication

Changzhi Zhao, Hailong Liu, Tianhe Xiao, Zichang Wang, Xiongwei Nie, Xinyun Li, Ping Qian, Liuxing Qin, Xiaosong Han, Jinfu Zhang, Jinxue Ruan, Mengjin Zhu, Yi‐Liang Miao, Bo Zuo, Kui Yang, , Shuhong Zhao

The paper uses CRISPR screening in porcine cells to identify host factors essential for Japanese encephalitis virus replication and entry.

bioRxiv · Nov 13, 2019 · PreprintGenetics