Patrick Rabe

Design and Evolution of an Orthogonal HaloTag for Multiplexed Labeling in Cells

This paper designs and evolves an orthogonal HaloTag variant (OrthoTag) that enables multiplexed labeling in cells with high specificity and orthogonality to the original HaloTag.

Biochemical characterisation of fungal bioluminescence enzymes reveals substrate inhibition and secondary turnover of 3-hydroxyhispidin by H3H

Drop on fixed target reaction initiation approach for serial and time resolved crystallography

This paper describes a drop on fixed target method for time-resolved serial crystallography, tested with enzymes to improve measurement consistency across facilities.

Targeting Mycobacterial Transpeptidases: Evaluating the Roles of Ldt and PBP Inhibition in Suppressing Mycobacterium smegmatis

This study evaluates the roles of Ldt and PBP inhibition in suppressing Mycobacterium smegmatis using beta-lactams and LdtMt2 inhibitors, finding stronger growth suppression with Ldt inhibition.

Cardiac stress leads to regulation of Filamin C dimerisation via an ancient phosphorylation-modulated interaction with HSPB7

The paper investigates how cardiac stress regulates Filamin C dimerisation through phosphorylation-modulated interactions with HSPB7, revealing evolutionary conservation of this mechanism.