Author

Che-Yuan Chang

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Anthony K. L. LeungiD· 2 shared Xingyi Yang· 2 shared Andrew MehleiD· 1 shared Anne Hamacher‐BradyiD· 1 shared Banhi BiswasiD· 1 shared Chenyao WangiD· 1 shared Danfeng CaiiD· 1 shared Elizabeth M Feltman· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersMicrobiology

Anthony K. L. LeungORCID

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2 papers

Recent·Most cited

Global remodeling of ADP-ribosylation by PARP1 suppresses influenza A virus infection

Zhenyu Zhang, Isabel R. Uribe, Kaitlin A. Davis, Robert Lyle McPherson, Gloria P. Larson, Mohsen Badiee, Vy Tran, Mitchell P. Ledwith, Elizabeth M Feltman, Shuǐqìng Yú, Yíngyún Caì, Che-Yuan Chang, Xingyi Yang, Zhuo Ma, Paul Chang, , Andrew Mehle

The paper shows influenza A virus infection increases global ADP-ribosylation, which inhibits viral replication, and identifies PARP1 as the main enzyme involved, with NS1 counteracting this effect.

Nature Communications · Dec 17, 2025Peer-reviewedMicrobiology

Interferon-Induced PARP14-Mediated ADP-Ribosylation in p62 Bodies Requires an Active Ubiquitin-Proteasome System

Rameez Raja, Banhi Biswas, Rachy Abraham, Yiran Wang, Che-Yuan Chang, Ivo Alexander Hendriks, Sara Charlotte Buch-Larsen, Hongrui Liu, Xingyi Yang, Chenyao Wang, Hien Vu, Anne Hamacher‐Brady, Danfeng Cai, Anthony K. L. Leung

This study shows interferon induces ADP-ribosylation in p62 bodies via PARP14, requiring ubiquitin activation and proteasome activity.

The EMBO Journal · Apr 7, 2025Peer-reviewedCell Biology