Sara Charlotte Buch-Larsen

This study identifies an ADP-ribosyl-cysteine degron in PARP7 that is recognized by DTX2, leading to PARP7 degradation and affecting AR signaling in prostate cancer.

The paper develops an MS-based workflow to detect Glu/Asp-ADPr modifications, identifies over 600 sites in cytokine-stimulated cells, and reveals residue-specific ADPr dynamics in immune signaling.

This paper develops a high-sensitivity single-cell proteomics platform and applies it to analyze small immune cells, achieving deep proteome coverage and identifying key markers in PBMCs.

This study shows interferon induces ADP-ribosylation in p62 bodies via PARP14, requiring ubiquitin activation and proteasome activity.

The paper identifies 14,056 citrullination sites across 4,008 proteins using mass spectrometry, revealing widespread citrullination and its functional roles in histone marks and autoantigens.

The paper identifies ADP-ribosylation sites regulated by HPF1 and ARH3 using proteomics, revealing widespread mono-ADP-ribosylation and challenges existing assumptions about PARP1 target residues.

The paper introduces AI-ETD for MS-based proteomics analysis of physiological ADP-ribosylation, identifying more ADPr sites than existing methods.

This study shows that PADI2-mediated citrullination is essential for oligodendrocyte differentiation, myelination, and motor function, with implications for remyelination therapies.

The paper introduces an advanced proteomics strategy using mass spectrometry to comprehensively profile ADP-ribosylation sites, identifying over 11,000 unique peptides and 7,000 sites in HeLa cells.