Author

Lani Tieu

University of California San Diego

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4 Genetics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:rat· 6 Approach:statistical model· 4 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

Giordano de GuglielmoiD· 6 shared Lieselot L. G. CarretteiD· 6 shared Marsida KallupiiD· 6 shared Olivier GeorgeiD· 6 shared Lauren C. SmithiD· 5 shared Molly BrennaniD· 5 shared Sharona SedighimiD· 5 shared Abraham A. PalmeriD· 4 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersNeuroscience

Giordano de GuglielmoORCID

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6 papers

Recent·Most cited

Genome-wide association study of cocaine self-administration behavior in Heterogeneous Stock rats

Montana Kay Lara, Lieselot L. G. Carrette, Thiago Missfeldt Sanches, Oksana Polesskaya, Alicia Avelar, Angela Beeson, Hassiba Beldjoud, Brent Boomhower, Molly Brennan, Denghui Chen, Riyan Cheng, Lindsey China, Apurva S. Chitre, Dana Conlisk, McKenzie J. Fannon, , Olivier George

This study performs a GWAS on cocaine self-administration in rats, identifying six genome-wide significant loci, including one linked to carboxylesterase genes involved in cocaine metabolism.

Nature Communications · Jun 11, 2026Peer-reviewedGenetics

Addiction-Like Severity Predicts Prolonged Oxycodone Withdrawal-Induced Allodynia in Genetically Diverse Rats

Sonja Lorean Plasil, Lani Tieu, Chengjia Qian, Natalie Taylor, Elizabeth A. Sneddon, Lieselot L. G. Carrette, Molly Brennan, Alex Morgan, Dyar N. Othman, Kathleen Bai, Sara Foroutani, Giordano de Guglielmo, Marsida Kallupi, Olivier George

This study shows that higher addiction-like severity in rats predicts prolonged oxycodone withdrawal-induced allodynia, with stronger associations between self-administration behaviors and pain sensitivity.

bioRxiv · May 18, 2026 · PreprintPharmacology & Toxicology

Large-scale characterization of cocaine addiction-like behaviors reveals that escalation of intake, aversion-resistant responding, and breaking-points are highly correlated measures of the same construct.

Giordano de Guglielmo, Lieselot L. G. Carrette, Marsida Kallupi, Molly Brennan, Brent Boomhower, Lisa Maturin, Dana Conlisk, Sharona Sedighim, Lani Tieu, McKenzie J. Fannon, Angelica R. Martinez, Nathan Velarde, Dyar N. Othman, Benjamin C. Sichel, Jarryd Ramborger, , Olivier George

The paper shows that escalation of cocaine intake, progressive ratio responding, and continued use despite adverse consequences are highly correlated in rats, with sex differences in addiction-like behaviors.

eLife · Nov 1, 2024Peer-reviewedNeuroscience

Individual differences in oxycodone addiction-like behaviors in a large cohort of heterogeneous stock (HS) rats

Marsida Kallupi, Giordano de Guglielmo, Lieselot L. G. Carrette, Sierra Simpson, Jenni Kononoff, Adam Kimbrough, Lauren C. Smith, Kokila Shankar, Alicia Avelar, Dana Conlisk, Molly Brennan, Lani Tieu, Sharona Sedighim, Brent Boomhower, Lisa Maturin, , Olivier George

The paper identifies individual differences in oxycodone addiction-like behaviors in HS rats to uncover genetic factors contributing to vulnerability and resilience.

bioRxiv · Jul 26, 2022 · PreprintNeuroscience

Identification of individual differences in response to methadone, buprenorphine, and naltrexone in animal models of opioid use disorder

Marsida Kallupi, Giordano de Guglielmo, Dana Conlisk, Molly Brennan, Lani Tieu, Sharona Sedighim, Brent Boomhower, Lauren C. Smith, Kokila Shankar, Lieselot L. G. Carrette, Sierra Simpson, Alicia Avelar, Lisa Maturin, Angelica R. Martinez, Ran Qiao, , Olivier George

The paper tests individual differences in response to methadone, buprenorphine, and naltrexone in rats with opioid use disorder, finding varying efficacy based on addiction severity.

bioRxiv · Jul 23, 2022 · PreprintNeuroscience

Vaping nicotine-containing electronic cigarettes produces addiction-like behaviors and cardiopulmonary abnormalities in rats

Lauren C. Smith, Marsida Kallupi, Lani Tieu, Abigail Jaquish, Jamie Barr, Yujuan Su, Nathan Velarde, Sharona Sedighim, Mike Klodnicki, Lieselot L. G. Carrette, Xin Sun, Giordano de Guglielmo, Olivier George

Vaping nicotine-containing e-cigarettes causes addiction-like behaviors and cardiopulmonary issues in rats, which are reduced by varenicline.

bioRxiv · Oct 8, 2019 · PreprintNeuroscience