Targeted degradation of SARS-CoV-2 via the autophagy-lysosome system using chemical mimetics of the N-degron pathway
Gee Eun Lee, Tae Hyun Bae, Uni Park, Jihoon Lee, Dong Won Lee, Young Jo Song, Se Hun Gu, Chi Ho Yu, Min‐Soo Kim, Luis Martínez‐Sobrido, Murim Choi, Jun-Gyu Park, Nam‐Hyuk Cho, Yong Tae Kwon, Ki Woon Sung
This study shows that chemical mimetics of the N-degron pathway, called ATLs, can degrade SARS-CoV-2 via autophagy-lysosome system in cells and animals.
bioRxiv · Sep 1, 2025 · PreprintMicrobiology