MicrobiologybioRxivPreprint
Targeted degradation of SARS-CoV-2 via the autophagy-lysosome system using chemical mimetics of the N-degron pathway
Gee Eun Lee, Tae Hyun Bae, Uni Park…·Ki Woon Sung
This study shows that chemical mimetics of the N-degron pathway, called ATLs, can degrade SARS-CoV-2 via autophagy-lysosome system in cells and animals.