Identification of protective human monoclonal antibodies using a K18 hACE2 transgenic mouse SARS-CoV-2 challenge model
Bhavesh R. Borate, Paula A. Pino, Amberlee Hicks, Juan Ignacio García, Andreu Garcia‐Vilanova, Chengjin Ye, Jun-Gyu Park, Billie Maingot, Oscar L. Rodriguez, Tracy Saveria, Drienna Holman, Sharon L. Schendel, Erica Ollmann Saphire, Luis Martínez‐Sobrido, Jordi Bertran Torrelles, Andrew J. Fiore-Gartland
This study identifies protective human monoclonal antibodies against SARS-CoV-2 using a K18 hACE2 transgenic mouse model, showing that in vivo testing improves accuracy over in vitro assays.
bioRxiv · Sep 13, 2025 · PreprintImmunology