Jihoon Lee

This study identifies ATB1071, a compound that activates p62-mediated mitophagy through Arg/N-degrons, showing therapeutic benefits in mitochondrial neuropathies and ischemia-reperfusion injury.

This paper demonstrates that AUTOTAC, a targeted degradation approach, reduces tau aggregates and improves symptoms in tauopathy models and companion dogs.

This study shows that chemical mimetics of the N-degron pathway, called ATLs, can degrade SARS-CoV-2 via autophagy-lysosome system in cells and animals.