Targeted degradation of pathologic tau aggregates via AUTOTAC ameliorates tauopathy
Jihoon Lee, Su Kim, Hye Yeon Kim, Gee Eun Lee, Dong Won Lee, Eun Hye Jung, Ji Su Lee, Eun Hye Cho, Hong‐Beom Park, Da-ha Park, Soon Chul Kwon, Jeong Eun Noh, Hyo Sun Cha, Hans Jin-young Oh, Seung Hoon Lee, , Yong Tae Kwon
This paper demonstrates that AUTOTAC, a targeted degradation approach, reduces tau aggregates and improves symptoms in tauopathy models and companion dogs.
bioRxiv · Sep 10, 2025 · PreprintNeuroscience