Hongyang Li

Alzheimers Disease Brain Phenotypes are Age-dependent

This paper shows that age information is essential for Alzheimer's Disease detection using brain MRI, outperforming age-invariant methods and revealing flaws in brain-age gap as a biomarker.

The ENCODE Imputation Challenge: A critical assessment of methods for cross-cell type imputation of epigenomic profiles

The paper evaluates 23 imputation models for cross-cell type epigenomic data, finding quality assessment challenging due to distributional shifts, data availability, and redundant metrics.

Expansive Linguistic Representations to Predict Interpretable Odor Mixture Discriminability

The paper uses semantic descriptors from language to predict odor mixture discriminability, outperforming existing methods by leveraging human perception data.

Micro-dissection and integration of long and short reads to create a robust catalog of kidney compartment-specific isoforms

The paper develops a pipeline combining micro-dissection and long/short-read sequencing to identify compartment-specific isoforms in kidney tissue, finding distinct isoform expression in glomerular and tubulo-interstitial compartments.

Leopard: fast decoding cell type-specific transcription factor binding landscape at single-nucleotide resolution

Leopard predicts TF-binding sites at single-nucleotide resolution with high accuracy and speed, outperforming existing methods.

DeepSleep: Fast and Accurate Delineation of Sleep Arousals at Millisecond Resolution by Deep Learning

DeepSleep uses deep learning to automatically detect sleep arousals in polysomnographic data with high accuracy, resolution, and speed.

Comparative structural dynamic analysis of GTPases

This study compares the structural dynamics of three GTPase superfamilies using MD simulations and network analysis, revealing similar dynamic features and coupling mechanisms across diverse families.

High throughput single cell sequencing of both T-cell-receptor-beta alleles

The paper develops a high-throughput method to analyze both T-cell-receptor-beta alleles in single cells using Next Generation Sequencing.