Two neuronal models of TDP-43 proteinopathy display reduced axonal translation, increased oxidative stress, and defective exocytosis.
Alessandra Pisciottani, Laura Croci, Fabio Lauria, Chiara Marullo, Elisa Savino, Alessandro Ambrosi, Paola Podini, Marta Marchioretto, Filippo Casoni, Ottavio Cremona, Stefano Taverna, Angelo Quattrini, Jean-Michel Cioni, Gabriella Viero, Franca Codazzi, G. Giacomo Consalez
This study characterizes two TDP-43 proteinopathy models in mouse neurons, revealing reduced axonal translation, increased oxidative stress, and presynaptic dysfunction linked to mRNA metabolism disruption.
Frontiers in Cellular Neuroscience · Nov 13, 2023Peer-reviewedNeuroscience