Marta Marchioretto

This study investigates how TDP-43 dysregulation disrupts protein synthesis in ALS models by altering ribosome dynamics and mRNA homeostasis, revealing a conserved mechanism across in vitro and in vivo systems.

This study characterizes two TDP-43 proteinopathy models in mouse neurons, revealing reduced axonal translation, increased oxidative stress, and presynaptic dysfunction linked to mRNA metabolism disruption.

The paper shows SMN protein binds ribosomes and modulates translation of specific mRNAs in SMA, causing translational defects in motor neuron-related proteins.

The paper identifies Hfq-mediated sRNA-target interactions in E. coli that facilitate adaptation to nutrient availability changes.

The paper introduces RiboLace, a method to isolate active ribosomes for ribosome profiling, enabling high-resolution analysis of active translation.