Enhancing hypercompact Cas{Phi}2 activity through EPICA.2, an optimized eukaryotic directed evolution platform
Giulia Vittoria Ruta, Matteo Ciciani, Veronica De Sanctis, Roberto Bertorelli, Chiara Valentini, Daniele Menghini, Eyemen Kheir, Michele Domenico Gentile, Alessio Conci, Antonio Casini, Anna Cereseto
The paper enhances Cas{Phi}2 activity using EPICA.2, an optimized directed evolution platform, resulting in evoCas{Phi}2 with 70-fold increased activity in human cells.
bioRxiv · Aug 17, 2026 · PreprintBioengineering