The paper investigates how centrosome architecture and m6A-dependent regulation influence p53 surveillance after whole-genome doubling, identifying key molecular mechanisms.

bioRxiv · Feb 25, 2026 · PreprintCell Biology

Polysomal profiling coupled to allele-specific proteomics reveals an EIF4H tranSNP allele possessing higher mRNA translation potential.

Meriem Hadjer Hamadou, Laura Alunno, Daniele Peroni, Michael Pancher, Fabio Mazza, Tecla Venturelli, Romina Belli, Erik Dassi, Alessandro Romanel, Alberto Inga

Molecular & Cellular Proteomics · Feb 20, 2026Peer-reviewedGenetics

A TranSNP in the DDIT4 mRNA can impact its translation efficiency and modulate p53-dependent responses in cancer cells

Meriem Hadjer Hamadou, Laura Alunno, Tecla Venturelli, Samuel Valentini, Davide Dalfovo, Francesca Lorenzini, Alessia Mattivi, Vincenza Vigorito, Glenda Paola Grupelli, Alessandro Mattè, Pamela Gatto, Michael Pancher, Chiara Valentini, Veronica De Sanctis, Roberto Bertorelli, , Alberto Inga

The paper identifies a tranSNP in DDIT4 mRNA that affects translation efficiency and modulates p53-dependent responses in cancer cells.

bioRxiv · Apr 2, 2025 · PreprintMolecular Biology

CD81-guided heterologous EVs present heterogeneous interactions with breast cancer cells

Elena Gurrieri, Giulia Carradori, Michela Roccuzzo, Michael Pancher, Daniele Peroni, Romina Belli, Caterina Trevisan, Michela Notarangelo, Wenqiu Huang, Ágata Sofia Assunção Carreira, Alessandro Quattrone, Guido W Jenster, Timo L.M. ten Hagen, Vito D’Agostino

The paper investigates how CD81-guided extracellular vesicles interact with breast cancer cells and deliver cargo, showing HER2 receptor influence on tropism and drug efficacy.

Journal of Biomedical Science · Oct 14, 2024Peer-reviewedMolecular Biology