Phase separation promotes Atg8 lipidation for autophagy progression
Yūko Fujioka, Takuma Tsuji, Tetsuya Kotani, Hiroyuki Kumeta, Chika Kakuta, Junko Shimasaki, Toyoshi Fujimoto, Hitoshi Nakatogawa, Nobuo N. Noda
This study shows that phase separation of the Atg1 complex forms the PAS, which facilitates Atg8 lipidation and autophagosome formation in yeast.
Nature Structural & Molecular Biology · Sep 16, 2025Peer-reviewedCell Biology