Author

Yuji Sakai

Yokohama City UniversityORCID 0000-0002-2184-4304Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Organism:yeast· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Assay:electronic health records· 1

Frequent Co-Authors

Nobuo N. NodaiD· 3 shared Tatsuro MaruyamaiD· 2 shared Aussie SuzukiiD· 1 shared Chika Kakuta· 1 shared Hitoshi NakatogawaiD· 1 shared Junko Shimasaki· 1 shared Kazuaki MatobaiD· 1 shared Keiichi InoueiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCell Biology

Nobuo N. NodaORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structural and mechanistic basis for membrane recognition and activation of the vacuolar lipase Atg15

Tomoko Kawamata, Nobuo N. Noda, Michiko Sasaki, Yoshinori Ohsumi, Yuji Sakai

This study identifies structural and mechanistic principles of Atg15 activation and membrane recognition using MD simulations and experimental validation.

Proceedings of the National Academy of Sciences · Jul 23, 2026Peer-reviewedCell Biology

CCAN forms the spherical shell-like structure in interphase kinetochores

Yuji Sakai, Mariko Ariyoshi, Yasuhiro Hirano, Aussie Suzuki, Toru Hirota, Masashi Tachikawa, Tatsuo Fukagawa

The paper shows that CCAN forms a spherical shell-like structure in interphase kinetochores using in silico and in vivo analyses.

bioRxiv · Jan 14, 2026 · PreprintMolecular Biology

Mitochondrial fission during mitophagy requires both inner and outer mitofissins

Kentaro Furukawa, Tatsuro Maruyama, Yuji Sakai, Shun‐ichi Yamashita, Keiichi Inoue, Tomoyuki Fukuda, Nobuo N. Noda, Tomotake Kanki

This study identifies Mfi2, a mitochondrial outer membrane microprotein required for mitophagy, showing that both inner and outer mitofissins are needed for mitochondrial fission during mitophagy.

EMBO Reports · Jan 13, 2026Peer-reviewedCell Biology

Atg1 phosphorylates Atg2 to gate phospholipid flow through a continuous conduit for autophagosome biogenesis

Yuji Sakai, Tetsuya Kotani, Tatsuro Maruyama, Kazuaki Matoba, Li Hao, Kuninori Suzuki, Chika Kakuta, Junko Shimasaki, Yuji Sugita, Tatsuya Niwa, Yūko Fujioka, Takuo Osawa, Hitoshi Nakatogawa, Nobuo N. Noda

The paper shows Atg1 phosphorylates Atg2 to enable lipid transport for autophagosome formation in yeast.

bioRxiv · May 24, 2025 · PreprintCell Biology