Metabolic alterations in the absence of a detectable neuromuscular phenotype in novel genomically humanised SOD1A4V mice.
David Thompson, Chloe Williams, Georgia Price, Andrew Paul Tosolini, Clemens Falker‐Gieske, Jonathan D. Gilthorpe, Giampietro Schiavo, Elizabeth Fisher, Thomas J. Cunningham
This study generates and analyzes a novel genomically humanised SOD1A4V mouse model, revealing metabolic dysfunction through multi-omic analyses and identifying it as a potential pre-symptomatic ALS model.
Brain Communications · Jan 1, 2026Peer-reviewedNeuroscience