Strain- and age-dependent features of the nigro-striatal circuit in three common laboratory mouse strains, C57BL/6J, A/J, and DBA/2J - Implications for Parkinson's disease modeling
Mélanie H. Thomas, Mona Karout, Beatriz Pardo Rodriguez, Yujuan Gui, Christian Jaeger, Alessandro Michelucci, Heike Kollmus, Klaus Schughart, Djalil Coowar, Rudi Balling, Michel Guy André Mittelbronn, Lasse Sinkkonen, Pierre Garcia, Manuel Buttini
This study examines age-related changes in the nigro-striatal circuit across three mouse strains, revealing strain-specific differences in dopaminergic neuron integrity and highlighting the importance of considering strain and age in Parkinson's disease research.
bioRxiv · Nov 30, 2020 · PreprintNeuroscience